Publications

2010

Birse RT, Choi J, Reardon K, Rodriguez J, Graham S, Diop S, Ocorr K, Bodmer R, Oldham S. High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. Cell Metab 2010;12(5):533-44.

Lee JH, Bodmer R, Bier E, Karin M. Sestrins at the crossroad between stress and aging. Aging 2010;2(6):369-74.

Luo N, Li G, Li Y, Fan X, Wang Y, Ye X, Mo X, Zhou J, Yuan W, Tan M, Xie H, Ocorr K, Bodmer R, Deng Y, Wu X. SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity. BMB Rep 2010;43(5):355-61.

Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell 2010;141(1):142-53.

Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 2010;327(5970):1223-8.

Hu J, Yuan W, Tang M, Wang Y, Fan X, Mo X, Li Y, Ying Z, Wan Y, Ocorr K, Bodmer R, Deng Y, Wu X. KBTBD7, a novel human BTB-kelch protein, activates transcriptional activities of SRE and AP-1.BMB Rep 2010;43(1):17-22.

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2009

Bowler M, Bodmer R. Social behavior in fission-fusion groups of red uakari monkeys (Cacajao calvus ucayalii). Am J Primatol 2009;71(12):976-87.

Alayari NN, Vogler G, Taghli-Lamallem O, Ocorr K, Bodmer R, Cammarato A. Fluorescent labeling of Drosophila heart structures. J Vis Exp 2009;(32). pii: 1423. doi: 10.3791/1423.

Wessells R, Fitzgerald E, Piazza N, Ocorr K, Morley S, Davies C, Lim HY, Elmén L, Hayes M, Oldham S, Bodmer R. d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila. Aging Cell 2009;8(5):542-52. Epub 2009 Jul 9.

Ocorr K, Fink M, Cammarato A, Bernstein S, Bodmer R. Semi-automated Optical Heartbeat Analysis of small hearts. J Vis Exp 2009;(31). pii: 1435. doi: 10.3791/1435.

Qian L, Bodmer R. Partial loss of GATA factor Pannier impairs adult heart function in Drosophila.Hum Mol Genet 2009;18(17):3153-63. Epub 2009 Jun 3.

Vogler G, Ocorr K. Visualizing the beating heart in Drosophila. J Vis Exp 2009;(31). pii: 1425. doi: 10.3791/1425.

Shahrestani P, Leung HT, Le PK, Pak WL, Tse S, Ocorr K, Huang T. Heterozygous mutation of Drosophila Opa1 causes the development of multiple organ abnormalities in an age-dependent and organ-specific manner. PLoS One 2009;4(8):e6867.

Buechling T, Akasaka T, Vogler G, Ruiz-Lozano P, Ocorr K, Bodmer R. Non-autonomous modulation of heart rhythm, contractility and morphology in adult fruit flies. Dev Biol 2009;328(2):483-92. Epub 2009 Feb 20.

Fink M, Callol-Massot C, Chu A, Ruiz-Lozano P, Izpisua Belmonte JC, Giles W, Bodmer R, Ocorr K. A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. Biotechniques 2009;46(2):101-13.

Mann T, Bodmer R, Pandur P. The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis. Development 2009;136(2):317-26. Epub 2008 Dec 15.

Leal SM, Qian L, Lacin H, Bodmer R, Skeath JB. Neuromancer1 and Neuromancer2 regulate cell fate specification in the developing embryonic CNS of Drosophila melanogaster. Dev Biol 2009;325(1):138-50. Epub 2008 Nov 1.

Akasaka T, Ocorr K. Drug discovery through functional screening in the Drosophila heart. Methods Mol Biol 2009;577:235-49.

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2008

Qian L, Mohapatra B, Akasaka T, Liu J, Ocorr K, Towbin JA, Bodmer R. Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease. Proc Natl Acad Sci U S A 2008;105(50):19833-8. Epub 2008 Dec 11.

Yu W, Li Y, Zhou X, Deng Y, Wang Z, Yuan W, Li D, Zhu C, Zhao X, Mo X, Huang W, Luo N, Yan Y, Ocorr K, Bodmer R, Wang Y, Wu X. A novel human BTB-kelch protein KLHL31, strongly expressed in muscle and heart, inhibits transcriptional activities of TRE and SRE. Mol Cells 2008;26(5):443-53.

Taghli-Lamallem O, Akasaka T, Hogg G, Nudel U, Yaffe D, Chamberlain JS, Ocorr K, Bodmer R. Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype. Aging Cell 2008;7(2):237-49. Epub 2008 Jan 23.

Li Y, Yang D, Bai Y, Mo X, Huang W, Yuan W, Yin Z, Deng Y, Murashko O, Wang Y, Fan X, Zhu C, Ocorr K, Bodmer R, Wu X. ZNF418, a novel human KRAB/C2H2 zinc finger protein, suppresses MAPK signaling pathway. Mol Cell Biochem 2008;310(1-2):141-51. Epub 2007 Dec 15.

Cammarato A, Dambacher CM, Knowles AF, Kronert WA, Bodmer R, Ocorr K, Bernstein SI. Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles. Mol Biol Cell 2008;19(2):553-62. Epub 2007 Nov 28.

Wang D, Tang B, Zhao G, Pan Q, Xia K, Bodmer R, Zhang Z. Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons. Mol Neurodegener 2008;3:3.

Liu J, Qian L, Han Z, Wu X, Bodmer R. Spatial specificity of mesodermal even-skipped expression relies on multiple repressor sites. Dev Biol 2008;313(2):876-86. Epub 2007 Oct 25.

Mery A, Taghli-Lamallem O, Clark KA, Beckerle MC, Wu X, Ocorr K, Bodmer R. The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function. J Exp Biol 2008;211(Pt 1):15-23.

Shaw P, Ocorr K, Bodmer R, Oldham S. Drosophila aging 2006/2007. Exp Gerontol 2008;43(1):5-10. Epub 2007 Dec 3.

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2007

Li J, Wang Y, Fan X, Mo X, Wang Z, Li Y, Yin Z, Deng Y, Luo N, Zhu C, Liu M, Ma Q, Ocorr K, Yuan W, Wu X. ZNF307, a novel zinc finger gene suppresses p53 and p21 pathway. Biochem Biophys Res Commun 2007;363(4):895-900. Epub 2007 Sep 10.

Ocorr KA, Crawley T, Gibson G, Bodmer R. Genetic variation for cardiac dysfunction in Drosophila. PLoS One 2007;2(7):e601.

Ocorr K, Perrin L, Lim HY, Qian L, Wu X, Bodmer R. Genetic control of heart function and aging in Drosophila. Trends Cardiovasc Med 2007;17(5):177-82.

Ocorr K, Reeves NL, Wessells RJ, Fink M, Chen HS, Akasaka T, Yasuda S, Metzger JM, Giles W, Posakony JW, Bodmer R. KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. Proc Natl Acad Sci U S A 2007;104(10):3943-8. Epub 2007 Feb 28.

Wessells RJ, Bodmer R. Cardiac aging. Semin Cell Dev Biol 2007;18(1):111-6. Epub 2006 Dec 27.

Wessells RJ, Bodmer R. Age-related cardiac deterioration: insights from Drosophila. Front Biosci 2007;12:39-48.

Ocorr K, Akasaka T, Bodmer R. Age-related cardiac disease model of Drosophila. Mech Ageing Dev 2007;128(1):112-6. Epub 2006 Nov 27.

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2006

Lim HY, Bodmer R, Perrin L. Drosophila aging 2005/06. Exp Gerontol 2006;41(12):1213-6. Epub 2006 Nov 28.

Liu M, Su M, Lyons GE, Bodmer R. Functional conservation of zinc-finger homeodomain gene zfh1/SIP1 in Drosophila heart development. Dev Genes Evol 2006;216(11):683-93. Epub 2006 Sep 7.

Zaffran S, Reim I, Qian L, Lo PC, Bodmer R, Frasch M. Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila. Development 2006;133(20):4073-83. Epub 2006 Sep 20.

Wang D, Qian L, Xiong H, Liu J, Neckameyer WS, Oldham S, Xia K, Wang J, Bodmer R, Zhang Z. Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc Natl Acad Sci U S A 2006;103(36):13520-5. Epub 2006 Aug 24.

Luong N, Davies CR, Wessells RJ, Graham SM, King MT, Veech R, Bodmer R, Oldham SM. Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity. Cell Metab 2006;4(2):133-42.

Akasaka T, Klinedinst S, Ocorr K, Bustamante EL, Kim SK, Bodmer R. The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman. Proc Natl Acad Sci U S A 2006;103(32):11999-2004. Epub 2006 Aug 1.

Choma MA, Izatt SD, Wessells RJ, Bodmer R, Izatt JA. Images in cardiovascular medicine: in vivo imaging of the adult Drosophila melanogaster heart with real-time optical coherence tomography. Circulation 2006;114(2):e35-6.

Liu J, Qian L, Wessells RJ, Bidet Y, Jagla K, Bodmer R. Hedgehog and RAS pathways cooperate in the anterior-posterior specification and positioning of cardiac progenitor cells. Dev Biol 2006;290(2):373-85. Epub 2006 Jan 4.

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2005

Qian L, Liu J, Bodmer R. Slit and Robo control cardiac cell polarity and morphogenesis. Curr Biol 2005;15(24):2271-8.

Fujioka M, Wessells RJ, Han Z, Liu J, Fitzgerald K, Yusibova GL, Zamora M, Ruiz-Lozano P, Bodmer R, Jaynes JB. Embryonic even skipped-dependent muscle and heart cell fates are required for normal adult activity, heart function, and lifespan. Circ Res 2005;97(11):1108-14. Epub 2005 Oct 20.

Krupp JJ, Yaich LE, Wessells RJ, Bodmer R. Identification of genetic loci that interact with cut during Drosophila wing-margin development. Genetics 2005;170(4):1775-95. Epub 2005 Jun 14.

Qian L, Liu J, Bodmer R. Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart. Dev Biol 2005;279(2):509-24.

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2004

Zimmer C, Tiveron MC, Bodmer R, Cremer H. Dynamics of Cux2 expression suggests that an early pool of SVZ precursors is fated to become upper cortical layer neurons. Cereb Cortex 2004;14(12):1408-20. Epub 2004 Jul 6.

Wessells RJ, Fitzgerald E, Cypser JR, Tatar M, Bodmer R. Insulin regulation of heart function in aging fruit flies. Nat Genet 2004;36(12):1275-81. Epub 2004 Nov 21.

Bier E, Bodmer R. Drosophila, an emerging model for cardiac disease. Gene 2004;342(1):1-11.

Wessells RJ, Bodmer R. Screening assays for heart function mutants in Drosophila. Biotechniques 2004;37(1):58-60, 62, 64 passim.

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2003

Han Z, Bodmer R. Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division. Development 2003;130(13):3039-51.

Klinedinst SL, Bodmer R. Gata factor Pannier is required to establish competence for heart progenitor formation. Development 2003;130(13):3027-38.

Holland ND, Venkatesh TV, Holland LZ, Jacobs DK, Bodmer R. AmphiNk2-tin, an amphioxus homeobox gene expressed in myocardial progenitors: insights into evolution of the vertebrate heart. Dev Biol 2003;255(1):128-37.

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2002

Han Z, Fujioka M, Su M, Liu M, Jaynes JB, Bodmer R. Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm. Dev Biol 2002;252(2):225-40.

Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H. MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation. Genes Cells 2002;7(8):835-50.

Lockwood WK, Bodmer R. The patterns of wingless, decapentaplegic, and tinman position the Drosophila heart. Mech Dev 2002;114(1-2):13-26.

Hardiman KE, Brewster R, Khan SM, Deo M, Bodmer R. The bereft gene, a potential target of the neural selector gene cut, contributes to bristle morphogenesis. Genetics 2002;161(1):231-47.

Yuan WZ, Bodmer R, Zhu CB, Wang YQ, Li YQ, Wu XS. [The use of RNAi as a technique to study the functions of heart-related genes in Drosophila]. Yi Chuan Xue Bao 2002;29(1):34-8.

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2001

Brewster R, Hardiman K, Deo M, Khan S, Bodmer R. The selector gene cut represses a neural cell fate that is specified independently of the Achaete-Scute-Complex and atonal. Mech Dev 2001;105(1-2):57-68.

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By Year

1983-2000 | 2001-2010 | 2011 - Present