Publications

2015

Smith, K.A., Voiriot, G., Tang, H., Fraidenburg, D.R., Song, S., Yamamura, H., Yamamura, A., Guo, Q., Wan, J., Pohl,N.M., Tauseef, M., Bodmer, R., Ocorr, K., Thistlethwaite, P.A., Haddad, G.G., Powell, F.L., Makino, A., Mehta, D., Yuan, J.X. Notch Activation of Ca2+ Signaling Mediates Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2015 Jan 8. [Epub ahead of print]

Diop, S. B., Bisharat, J., Birse, R., Oldham, S., Ocorr, K. Bodmer, R. PGC-1/spargel counteracts high fat diet-induced obesity and cardiac lipotoxicity downstream of TOR and Brummer ATGL lipase. Cell Reports 2015 (In Press)

2014

Nishimura M, Kumsta C, Kaushik G, Ding Y,Bisharat-Kernizan J,Cammarato A, Ross RS, Engler AJ, Bodmer R, Hansen, M. and Ocorr, K. A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging. Aging Cell 2014 Jan 9; doi: 10.1111/acel.12193. PMID: 24400780.

Lim, H.-Y., Wang, W., Chen, J., Ocorr, K. and Bodmer, R. ROS regulate cardiac function in Drosophila via a novel paracrine mechanism. Cell Rep. 2014 Apr. 7(1):35-44. doi: 10.1016/j.celrep.2014.02.029. Epub 2014 Mar 20.

Ocorr, K., Vogler, G., Bodmer, R. Methods to assess Drosophila heart development, function and aging. Methods 68 (2014), pp. 265-272 DOI information: 10.1016/j.ymeth.2014.03.031

Reed. L.K., Lee, K., Zhang, Z., Rashid, L., Poe, A., Hsieh, B., Deighton, N., Glassbrook, N., Bodmer, R., Gibson, G. Systems genomics of metabolic phenotypes in wild-type Drosophila melanogaster. Genetics. 2014 Jun;197(2):781-93. doi: 10.1534/genetics.114.163857. Epub 2014 Mar 25.

Vogler, G., Liu, J., Iafe T.W., Migh, E., Mihaly, J., Bodmer, R. Cdc42 and formin activity control non-muscle myosin dynamics during Drosophila heart morphogenesis. J Cell Biol. 2014 Sep 29;206(7):909-22. doi: 10.1083/jcb.201405075.

2013

Na J, Musselman LP, Pendse J, Baranski TJ, Bodmer R, Ocorr K, Cagan R. A Drosophila model of high sugar diet-induced cardiomyopathy. PLoS Genet. 2013;9(1):e1003175. doi: 10.1371/journal.pgen.1003175. Epub 2013 Jan 10. PMCID: 3542070.

Zhang Z, Hsieh B, Poe A, Anderson J, Ocorr K, Gibson G, Bodmer R. Complex genetic architecture of cardiac disease in a wild type inbred strain of Drosophila melanogaster. PLoS One. 2013 Apr 29;8(4):e62909. doi: 10.1371/journal.pone.0062909. Print 2013.

Rahman MM, Sykiotis GP, Nishimura M, Bodmer R, Bohmann D. Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes. Aging Cell. 2013 Aug;12(4):554-62. doi: 10.1111/acel.12078. Epub 2013 May 16.

Nirala NK, Rahman M, Walls SM, Singh A, Zhu LJ, Bamba T, Fukusaki E, Srideshikan SM, Harris GL, Ip YT, Bodmer R, Acharya UR. Survival Response to Increased Ceramide Involves Metabolic Adaptation through Novel Regulators of Glycolysis and Lipolysis. PLoS Genet. 2013 Jun;9(6):e1003556. doi: 10.1371/journal.pgen.1003556. Epub 2013 Jun 20.

Harpaz N, Ordan E, Ocorr K, Bodmer R, Volk T. Multiplexin promotes heart but not aorta morphogenesis by polarized enhancement of slit/robo activity at the heart lumen. PLoS Genet. 2013 Jun;9(6):e1003597. doi: 10.1371/journal.pgen.1003597. Epub 2013 Jun 27.

Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin YF, Ocorr K, Kang G, Chen J, Stainier DY, Yelon D, Chi NC. In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature. 2013 Jun 27;498(7455):497-501. doi: 10.1038/nature12322. Epub 2013 Jun 19.

Dubchak I, Munoz M, Poliakov A, Salomonis N, Minovitsky S, Bodmer R, Zambon AC. Whole-Genome rVISTA: a tool to determine enrichment of transcription factor binding sites in gene promoters from transcriptomic data. Bioinformatics. 2013 Jul 3. [Epub ahead of print]

Min Tang, Wuzhou Yuan, Xiongwei Fan, Ming Liu, Rolf Bodmer, Karen Ocorr and Xiushan Wu. Pygopus Maintains Heart Function in Aging Drosophila Independently of Canonical Wnt Signaling. Cardiovascular Genetics. September 17, 2013, doi: 10.1161/​CIRCGENETICS.113.000253.

Heinrichsen, E.T., Zhang, H., Robinson, J.E., Ngo, J., Diop, S., Bodmer, R., Joiner, W.J., Metallo, C.M., Haddad, G.G. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Mol Metabolism 2013 Oct 23;3(1):42-54. doi: 10.1016/j.molmet.2013.10.003. eCollection 2014.

Tang M, Yuan W, Bodmer R, Wu X, Ocorr K. The role of pygopus in the differentiation of intra-cardiac valves in Drosophila. Genesis. 2013 Nov 8. doi: 10.1002/dvg.22724. [Epub ahead of print]

Melkani GC, Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K. Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart. PLoS Genet. 2013 December; 9(12): e1004024.

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2012

Scimia MC, Hurtado C, Ray S, Metzler S, Wei K, Wang J, Woods CE, Purcell NH, Catalucci D, Akasaka T, Bueno OF, Vlasuk GP, Kaliman P, Bodmer R, Smith LH, Ashley E, Mercola M, Brown JH, Ruiz-Lozano P. APJ acts as a dual receptor in cardiac hypertrophy. Nature 2012;488(7411):394-8.

Kaushik G, Zambon AC, Fuhrmann A, Bernstein SI, Bodmer R, Engler AJ, Cammarato A. Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction. J Cell Mol Med 2012;16(8):1656-62. doi: 10.1111/j.1582-4934.2011.01517.x.

Spindler SR, Li R, Dhahbi JM, Yamakawa A, Mote P, Bodmer R, Ocorr K, Williams RT, Wang Y, Ablao KP. Statin Treatment Increases Lifespan and Improves Cardiac Health in Drosophila by Decreasing Specific Protein Prenylation. PLoS ONE 2012;7(6): e39581. doi:10.1371/journal.pone.0039581

Choo YS, Vogler G, Wang D, Kalvakuri S, Iliuk A, Tao WA, Bodmer R, Zhang Z. Regulation of parkin and PINK1 by neddylation. Hum Mol Genet 2012;21, 2514-2523. Epub 2012 Mar 2.

Diop SB, Bodmer R. Drosophila as a model to study the genetic mechanisms of obesity-associated heart dysfunction. J Cell Mol Med 2012;16(5):966-71. doi: 10.1111/j.1582-4934.2012.01522.x.

Qian L, Bodmer R. Probing the polygenic basis of cardiomyopathies in Drosophila. J Cell Mol Med 2012;16(5):972-7. doi: 10.1111/j.1582-4934.2012.01529.x.

Hong TT, Smyth JW, Chu KY, Vogan JM, Fong TS, Jensen BC, Fang K, Halushka MK, Russell SD, Colecraft H, Hoopes CW, Ocorr K, Chi NC, Shaw RM. BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. Heart Rhythm 2012;9(5):812-20. Epub 2011 Dec 2.

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2011

Pickles RS, Groombridge JJ, Zambrana Rojas VD, Van Damme P, Gottelli D, Kundu S, Bodmer R, Ariani CV, Iyengar A, Jordan WC. Evolutionary history and identification of conservation units in the giant otter, Pteronura brasiliensis. Mol Phylogenet Evol 2011;61(3):616-27. Epub 2011 Sep 8.

Grossman TR, Gamliel A, Wessells RJ, Taghli-Lamallem O, Jepsen K, Ocorr K, Korenberg JR, Peterson KL, Rosenfeld MG, Bodmer R, Bier E. Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects.PloS One Genetics 2011; 7(11):e1002344. Epub 2011 Nov 3.

Birse RT, Bodmer R. Lipotoxicity and cardiac dysfunction in mammals and Drosophila. Crit Rev Biochem Mol Biol 2011;46(5):376-85. Epub 2011 Aug 19.

Melkani GC, Bodmer R, Ocorr K, Bernstein SI. The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model. PloS One 2011;6(7):e22579. Epub 2011 Jul 25.

Eleftherianos I, Won S, Chtarbanova S, Squiban B, Ocorr K, Bodmer R, Beutler B, Hoffmann JA, Imler JL. ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections. Proc Natl Acad Sci U S A 2011;108(29):12024-9. Epub 2011 Jun 30.

Lim HY, Bodmer R. Phospholipid homeostasis and lipotoxic cardiomyopathy: a matter of balance. Fly 2011;5(3):234-6. Epub 2011 Jul 1.

Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R. Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol 2011;193(7):1181-96. Epub 2011 Jun 20.

Nishimura M, Ocorr K, Bodmer R, Cartry J. Drosophila as a model to study cardiac aging. Exp Gerontol 2011;46(5):326-30. Epub 2010 Dec 3.

Cammarato A, Ahrens CH, Alayari NN, Qeli E, Rucker J, Reedy MC, Zmasek CM, Gucek M, Cole RN, Van Eyk JE, Bodmer R, O'Rourke B, Bernstein SI, Foster DB. A mighty small heart: the cardiac proteome of adult Drosophila melanogaster. PLoS One 2011;6(4):e18497.

Fan X, Yang Q, Wang Y, Zhang Y, Wang J, Yuan J, Li Y, Wang Y, Deng Y, Yuan W, Mo X, Wan Y, Ocorr K, Yang X, Wu X. Cloning and characterization of the cardiac-specific Lrrc10 promoter. BMB Rep 2011;44(2):123-8.

Huang W, Deng Y, Dong W, Yuan W, Wan Y, Mo X, Li Y, Wang Z, Wang Y, Ocorr K, Zhang B, Lin S, Wu X. The effect of excess expression of GFP in a novel heart-specific green fluorescence zebrafish regulated by nppa enhancer at early embryonic development. Mol Bio Rep 2011;38(2):793-9. Epub 2010 Apr 10.

Lim HY, Wang W, Wessells RJ, Ocorr K, Bodmer R. Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. Genes Dev 2011;25(2):189-200.

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By Year

1983-2000 | 2001-2010 | 2011 - Present