Cell Reports - ROS regulate cardiac function in Drosophila via a novel paracrine mechanism. PLoS Genetics - Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart. PLoS Genetics - A Drosophila model of high sugar diet-induced cardiomyopathy. Cell - A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Science - Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Molecular Biology of the Cell - Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles. Neuron - Neurogenesis of the peripheral nervous system in Drosophila embryos: DNA replication patterns and cell lineages.


Smith, K.A., Voiriot, G., Tang, H., Fraidenburg, D.R., Song, S., Yamamura, H., Yamamura, A., Guo, Q., Wan, J., Pohl,N.M., Tauseef, M., Bodmer, R., Ocorr, K., Thistlethwaite, P.A., Haddad, G.G., Powell, F.L., Makino, A., Mehta, D., Yuan, J.X. Notch Activation of Ca2+ Signaling Mediates Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2015 Jan 8. [Epub ahead of print]

Diop, S. B., Bisharat, J., Birse, R., Oldham, S., Ocorr, K. Bodmer, R. PGC-1/spargel counteracts high fat diet-induced obesity and cardiac lipotoxicity downstream of TOR and Brummer ATGL lipase. Cell Reports 2015 (In Press)


Nishimura M, Kumsta C, Kaushik G, Ding Y,Bisharat-Kernizan J,Cammarato A, Ross RS, Engler AJ, Bodmer R, Hansen, M. and Ocorr, K. A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging. Aging Cell 2014 Jan 9; doi: 10.1111/acel.12193. PMID: 24400780.

Lim, H.-Y., Wang, W., Chen, J., Ocorr, K. and Bodmer, R. ROS regulate cardiac function in Drosophila via a novel paracrine mechanism. Cell Rep. 2014 Apr. 7(1):35-44. doi: 10.1016/j.celrep.2014.02.029. Epub 2014 Mar 20.

Ocorr, K., Vogler, G., Bodmer, R. Methods to assess Drosophila heart development, function and aging. Methods 68 (2014), pp. 265-272 DOI information: 10.1016/j.ymeth.2014.03.031

Reed. L.K., Lee, K., Zhang, Z., Rashid, L., Poe, A., Hsieh, B., Deighton, N., Glassbrook, N., Bodmer, R., Gibson, G. Systems genomics of metabolic phenotypes in wild-type Drosophila melanogaster. Genetics. 2014 Jun;197(2):781-93. doi: 10.1534/genetics.114.163857. Epub 2014 Mar 25.

Vogler, G., Liu, J., Iafe T.W., Migh, E., Mihaly, J., Bodmer, R. Cdc42 and formin activity control non-muscle myosin dynamics during Drosophila heart morphogenesis. J Cell Biol. 2014 Sep 29;206(7):909-22. doi: 10.1083/jcb.201405075.


Na J, Musselman LP, Pendse J, Baranski TJ, Bodmer R, Ocorr K, Cagan R. A Drosophila model of high sugar diet-induced cardiomyopathy. PLoS Genet. 2013;9(1):e1003175. doi: 10.1371/journal.pgen.1003175. Epub 2013 Jan 10. PMCID: 3542070.

Zhang Z, Hsieh B, Poe A, Anderson J, Ocorr K, Gibson G, Bodmer R. Complex genetic architecture of cardiac disease in a wild type inbred strain of Drosophila melanogaster. PLoS One. 2013 Apr 29;8(4):e62909. doi: 10.1371/journal.pone.0062909. Print 2013.

Rahman MM, Sykiotis GP, Nishimura M, Bodmer R, Bohmann D. Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes. Aging Cell. 2013 Aug;12(4):554-62. doi: 10.1111/acel.12078. Epub 2013 May 16.

Nirala NK, Rahman M, Walls SM, Singh A, Zhu LJ, Bamba T, Fukusaki E, Srideshikan SM, Harris GL, Ip YT, Bodmer R, Acharya UR. Survival Response to Increased Ceramide Involves Metabolic Adaptation through Novel Regulators of Glycolysis and Lipolysis. PLoS Genet. 2013 Jun;9(6):e1003556. doi: 10.1371/journal.pgen.1003556. Epub 2013 Jun 20.

Harpaz N, Ordan E, Ocorr K, Bodmer R, Volk T. Multiplexin promotes heart but not aorta morphogenesis by polarized enhancement of slit/robo activity at the heart lumen. PLoS Genet. 2013 Jun;9(6):e1003597. doi: 10.1371/journal.pgen.1003597. Epub 2013 Jun 27.

Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin YF, Ocorr K, Kang G, Chen J, Stainier DY, Yelon D, Chi NC. In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature. 2013 Jun 27;498(7455):497-501. doi: 10.1038/nature12322. Epub 2013 Jun 19.

Dubchak I, Munoz M, Poliakov A, Salomonis N, Minovitsky S, Bodmer R, Zambon AC. Whole-Genome rVISTA: a tool to determine enrichment of transcription factor binding sites in gene promoters from transcriptomic data. Bioinformatics. 2013 Jul 3. [Epub ahead of print]

Min Tang, Wuzhou Yuan, Xiongwei Fan, Ming Liu, Rolf Bodmer, Karen Ocorr and Xiushan Wu. Pygopus Maintains Heart Function in Aging Drosophila Independently of Canonical Wnt Signaling. Cardiovascular Genetics. September 17, 2013, doi: 10.1161/​CIRCGENETICS.113.000253.

Heinrichsen, E.T., Zhang, H., Robinson, J.E., Ngo, J., Diop, S., Bodmer, R., Joiner, W.J., Metallo, C.M., Haddad, G.G. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Mol Metabolism 2013 Oct 23;3(1):42-54. doi: 10.1016/j.molmet.2013.10.003. eCollection 2014.

Tang M, Yuan W, Bodmer R, Wu X, Ocorr K. The role of pygopus in the differentiation of intra-cardiac valves in Drosophila. Genesis. 2013 Nov 8. doi: 10.1002/dvg.22724. [Epub ahead of print]

Melkani GC, Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K. Huntington's Disease Induced Cardiac Amyloidosis Is Reversed by Modulating Protein Folding and Oxidative Stress Pathways in the Drosophila Heart. PLoS Genet. 2013 December; 9(12): e1004024.

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